alk kinase inhibitor-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6409	ALK kinase inhibitor-1	SAR348830	Others
	SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.		Others
T11184	EML4-ALK kinase inhibitor 1	EML4 ALK kinase inhibitor 1,EML4-ALK kinase inhibitor 1	ALK
	EML4-ALK kinase inhibitor 1 (EML4 ALK kinase inhibitor 1) is a potent oral active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM.		ALK
T10285	ALK inhibitor 1		FAK , IGF-1R , ALK
	ALK inhibitor 1 is a selective ALK kinase inhibitor.		FAK , IGF-1R , ALK
T11254	F-1		ROS , ALK , ROS Kinase
	F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathwa...		ROS , ALK , ROS Kinase
T3059	ALK-IN-1	AP26113,Brigatinib,AP26113-analog	EGFR , IGF-1R , ALK
	ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.		EGFR , IGF-1R , ALK
T4015	HG-14-10-04		ALK
	HG-14-10-04 is a potent and specific ALK inhibitor.		ALK
T2641	KRCA-0008	KRCA 0008,KRCA0008	ACK , ALK
	KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.		ACK , ALK
T16708	R-268712		ALK , TGF-beta/Smad
	R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor.		ALK , TGF-beta/Smad
T2251	NVP-TAE 684	TAE684	Apoptosis , ALK
	NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).		Apoptosis , ALK
T1936	Alectinib	RG-7853,AF802,CH5424802,AF-802	VEGFR , Tyrosine Kinases , ALK
	Alectinib (RG-7853) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.		VEGFR , Tyrosine Kinases , ALK
T3061	Lorlatinib	PF-6463922,PF-06463922,Loratinib	Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase
	Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity.		Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase
T3678	Entrectinib	RXDX-101,NMS-E628	Trk receptor , ROS , ALK , Autophagy , ROS Kinase
	Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectini...		Trk receptor , ROS , ALK , Autophagy , ROS Kinase
T8399	Crizotinib hydrochloride	PF-02341066 hydrochloride	c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
	Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)		c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
T62613	ALK5-IN-26
	ALK5-IN-26 (EX-22) is an ALK (Activin receptor-like kinase) inhibitor. ALK5-IN-26 inhibits ALK5 (IC50 ≤ 1 nM).
T70060	PF-06463922 acetate
	PF-06463922 acetate is a potent, selective brain-penetrable inhibitor of both anaplastic lymphoma kinase (ALK) and c-ros Oncogene 1 (ROS1) with strong activity against all known ALK and ROS1 mutants identified in patient...
T38584	ALK-IN-12
	ALK-IN-12 is a highly potent and orally active inhibitor of anaplastic lymphoma kinase (ALK), demonstrating an exceptional IC50 value of 0.18 nM. Additionally, ALK-IN-12 displays inhibitory activity against insulin-like ...
T83856	AP-1
	AP-1, a miniaturized proteolysis-targeting chimera (PROTAC) incorporating an anaplastic lymphoma kinase (ALK) ligand connected to (±)-thalidomide via an ultrashort linker, effectively degrades ALK fusion proteins such as...